… the analysis of new toxicological and exposure data, resulting in human exposure guidelines
… into regulatory practice. Future perspectives on the continued evolution of toxicity testing to …

… rodent acute oral toxicity data was curated by US EPA and NICEATM and used as the basis
… for acute oral systemic toxicity, targeted towards regulatory needs identified across federal …

… a formal regulatory document, the FDA continues to ignore already collated data on toxicity
profiles, rather they are taking a precautionary approach to the regulation of Nanomedicine, …

… and follow the tier toxicity testing approach proposed for food … in the light of the toxicity data
and toxicokinetics available; if … the European and American regulatory framework as well as …

… the regulation of PFAS than the current approach of regulating only … However, a similar
additive toxicity approach could … RPF approach is currently limited by the database of toxicity data …

… To increase the regulatory use and acceptance of NAMs for biokinetics for these ADME …
activity concept to facilitate the use of in vitro toxicity data for risk assessment. Environ Sci …

… Toxicity data have been generated using nanomaterials, cigarette smoke, … toxicity assessments
and therapeutic development at lower cost. In line with these goals, US federal regulatory …

… Based on this approach, an oral RfD of 0.04 mg Cu/kg/day … RfD for copper thus needs to
consider toxicity data in animals, human … the current knowledge on copper toxicity, assess dose-…

… Our study is an important step towards a harmonized approach accepted by regulatory … +
coformulants), the toxicity data requirements are currently limited to acute systemic toxicity (oral, …

… approach is the electrochemical methods used to fabricate … often used to assess nanomaterial
toxicity, data comparison is … as mice and rats) are used for in vivo toxicity testing. In urban …